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IVISense™ Hypoxia CA IX 680 (HypoxiSense™ 680) is a carbonic anhydrase IX (CA IX) targeted fluorescent in vivo imaging probe that can be used to image CA IX overexpression in response to hypoxia. Oxygen deprivation is associated with several disease states including angiogenisis, pulmonary disease, inflammation, and cancer.For research use only. Not for use in diagnostic procedures.
IVISense™ Renin 680 FAST (ReninSense™) is recognized and activated by rodent forms of renin in preclinical in vivo imaging models. IVISense Renin 680 FAST may be used to monitor abnormal Renin-Angiotensin System (RAS) function, progression of disease, and the efficacy of therapeutic treatment in disorders such as hypertension, cardiovascular disease, as well as some neurological diseases. For research use only. Not for use in diagnostic procedures.
IVISense™ Cat K 680 FAST NIR fluorescent probe enables monitoring and quantifying cathepsin K (Cat K) activity.Cat K is a lysosomal cysteine protease expressed in osteoclasts, chondrocytes, and synovial fibroblasts and is involved in bone resorption and collagen degradation. Women with osteoporosis, breast cancer and bone metastases are reported to have high levels of Cat K. The high expression levels of Cat K is a good marker for not only better understanding bone modeling and remodeling, but evaluating inhibitors of Cat K for potential therapeutics.For research use only. Not for use in diagnostic procedures.
IVISense™ Cat B FAST fluroescent probes enable non-invasive in vivo detection of disease status and progression in oncology, inflammation and other areas associated with Cat B activity.Associated with tumor aggression, cathepsins are a family of proteases that are pivotal components of signaling pathways that can enhance cancer cell growth and inflammation. Within the human lysosomal cysteine cathepsin family, there are 11 members, including cathepsin B, L, S, and Plasmin. As a family, cysteine cathepsins are involved in the response to anticancer therapy within the tumor microenvironment and play crucial roles in the development of resistance to therapeutics. In particular, cathepsin B expression correlates with the invasive and metastatic capabilities of many tumors, such as in breast cancer where high expression levels of cathepsin B have been linked to highly aggressive tumors. Cathepsin B is also upregulated in a variety of inflammatory cells (including eosinophils, neutrophils, and macrophages).
IVISense™ Folate Receptor 680 fluorescence imaging probe (FolateRSense™) is highly specific and sensitive in its detection of Folate Receptor alpha (FRa). Used with in vivo imaging systems such as Revvity's industry leading IVIS® platform, this targeted probe enables the non-invasive visualization and quantification of FR expression in highly metabolic cells such as tumor cells.
In vivo optical imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. In oncology, increases in tumor vascular permeability can be an early indicator of tumor angiogenesis. In inflammatory disease increased vascular permeability can indicate alterations in fluid homeostasis in an acute edema response or in chronic organ conditions.Revvity’s IVISense™ Vascular NIR fluorescent probes (AngioSense®) are designed to evaluate vascular changes to better understand various disease states or provide valuable information on the effects of drug candidates earlier in the development process.
IVISense™ Bombesin Receptor 680 (BombesinRSense™ 680) is a targeted NIR fluorescent probe for in vivo imaging applications that targets bombesin receptors expressed in many types of cancers.For research use only. Not for use in diagnostic procedures.
IVISense™ GFR 680 (GFR-Vivo™) is a NIR fluorescent inulin based probe that enables quantitative assessment of renal Glomerular Filtration Rate (GFR), as an indicator of renal toxicity or injury.For research use only. Not for use in diagnostic procedures.
Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time. Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.
Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism. Revvitys IVISense™ Transferrin Receptor 750 fluorescent probe (Transferrin-Vivo™) is a NIR-labeled in vivo imaging probe that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. IVISense Transferrin Receptor 750 fluorescent agent also detects normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.
IVISense™ Annexin-V 750 fluorescent imaging probe (Annexin-Vivo™) is designed to enable in vivo visualization and quantification of membrane-bound phosphatidylserine (PS) during the early stages of apoptosis.For research use only. Not for use in diagnostic procedures.
IVISense™ Edema (Superhance™ 680) fluorescent probe is a blood pooling imaging agent for imaging circulation, blood vessels, vasculature, vascular leak, including that associated with early oncologic and ophthalmologic lesions. This agent has a short pharmacokinetic profile with bladder clearance, and binds to albumin in blood for a modestly extended (30m-1h) circulation half-life.For research use only. Not for use in diagnostic procedures.
Neutrophil Elastase (NE) is a protease secreted by neutrophils. Neutrophils are the first responders of the innate immune system and play a crucial role in fighting invading pathogens. Thought to be indiscriminate killers, research shows neutrophils are implicated in chronic inflammatory diseases and contribute to injury repair.Better understand neutrophilic response in vivo with IVISense™ Neutrophil Elastase 680 FAST NIR fluorescent probe. IVISense Neutrophil Elastase 680 probe can detect NE post-degranulation or netosis from activated neutrophils.For research use only. Not for use in diagnostic procedures.
Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.Revvity’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.
IVISense™ Acute Vascular (Genhance™) fluorescent probes enable imaging and quantitation of acute vascular permeability increase, bladder clearance via intravital ureter imaging, or incorporation into liposomes for drug delivery monitoring.For research use only. Not for use in diagnostic procedures.
IVISense™ Gastrointestinal 750 (GastroSense™ 750) is a near-infrared, fluorescently-labeled macromolecule that can be used to monitor the effects of disease or drugs on gastric motility and or gastric emptying. It may also be used as an anatomical marker for the gastrointestinal tract. For research use only. Not for use in diagnostic procedures.
Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. Revvity's IVISsense™ Integrin Receptor fluorescent probes (IntegriSense™) are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
IVISense™ Tomato Lectin 680 fluorescent probe (TLectinSense™) is a NIR labeled macromolecule that targets the vasculature and enables imaging of blood vessels and angiogenesis. This imaging probe labels endothelial cells and when used in conjunction with optical imaging systems such as Revvity's industry leading IVIS® platform, can be used to non-invasively assess tumor vasculature in response to an anti-angiogenic drug, or to assess vascular burden as another biological consideration.
Image and quantify osteoporosis, arthritis, cancer metastases, and other bone diseases, as well as normal bone growth and resorption, in vivo with IVISense™ Osteo Fluorescent Imaging probes (OsteoSense™). As opposed to other imaging modalities such as CT or x-ray which raise the risk of harmful irradiation to the subject, in vivo fluorescence imaging offers no radiation exposure concerns, and when performed with optimized hydroxyapatite-targeted probes such as IVISense Osteo, can image and quantify bone growth and elucidate the biology of bone remodeling.IVISense Osteo probes are available in 3 wavelengths: 680, 750, and 800.