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IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)

Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

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Save 10% on your first Revvity.com order. Use promo code below.
HELLO10
Feature Specification
Unit Size 1 vial (10 doses)
Specificity Cathepsin proteases

Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

Click to copy promo code to clipboard.
Save 10% on your first Revvity.com order. Use promo code below.
HELLO10
Product Variants
Wave Length: 680 nm
Part #:
NEV10003
List Price
USD 581.26
Wave Length: 750 nm
Part #:
NEV10001EX
List Price
USD 612.39
Wave Length: 750 nm
Style
FAST
Part #:
NEV11171
List Price
USD 676.29
For research use only. Not for use in diagnostic procedures.
USD 676.29
Your Price: Login to view

Overview

IVISense Pan Cathepsin 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. IVISense Pan Cathepsin 750 FAST offers faster activation after injection; it can be imaged at earlier times for optimized work flow, or for applications such as acute inflammation models. 4-24h imaging at 750 nm.

Specifications

Brand
IVISense
Fluorescent Agent Type
Enzyme activated
Imaging Modality
Fluorescence
Shipping Conditions
Shipped in Blue Ice
Specificity
Cathepsin proteases
Storage Conditions
+2 to +8 °C
Style
FAST
Therapeutic Area
Arthritis
Atherosclerosis
Inflammation
Oncology
Pulmonary
Vascular
Unit Size
1 vial (10 doses)
Wave Length
750 nm

Resources

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Best practices for designing an effective in vivo fluorescence imaging study

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Detect and monitor protease-related biological processes in vivo with IVISense Pan Cathepsin fluorescent probes
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Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing...

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Noninvasive in vivo quantitation of asthma severity using IVISense fluorescent probes

This app note highlights using IVISense Pan Cathepsin 680 NIR fluorescent probe for noninvasive in vivo imaging and quantitation...

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