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IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)
IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)
Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.
Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.
| Feature | Specification |
|---|---|
| Unit Size | 1 vial (10 doses) |
| Specificity | Cathepsin proteases |
Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.
Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.
IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)
IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)
Product information
Overview
IVISense Pan Cathepsin 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. IVISense Pan Cathepsin 750 FAST offers faster activation after injection; it can be imaged at earlier times for optimized work flow, or for applications such as acute inflammation models. 4-24h imaging at 750 nm.
Specifications
| Brand |
IVISense
|
|---|---|
| Fluorescent Agent Type |
Enzyme activated
|
| Imaging Modality |
Fluorescence
|
| Shipping Conditions |
Shipped in Blue Ice
|
| Specificity |
Cathepsin proteases
|
| Storage Conditions |
+2 to +8 °C
|
| Style |
FAST
|
| Therapeutic Area |
Arthritis
Atherosclerosis
Inflammation
Oncology
Pulmonary
Vascular
|
| Unit Size |
1 vial (10 doses)
|
| Wave Length |
750 nm
|
Resources
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In vivo fluorescence imaging displays a very broad utility and has become a well-established modality for functional imaging in...
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