LabChip GX Touch | DNA and RNA sizing and quantitation

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LabChip GX Touch HT Nucleic Acid Analyzer

The LabChip® GX Touch™ nucleic acid analyzer leverages microfluidic technology enabling DNA and RNA quantitation and sizing to be done in seconds via automated capillary electrophoresis separation. It is optimal for:

Fast, high-throughput QC analysis of NGS libraries
NGS library preparation (smear and fragment analysis) and quality control
RNA and DNA fragment analysis (including cell-free DNA, DNA isolated from FFPE samples, and PCR-free libraries)
Quantitation and qualification for CRISPR fragment analysis
Screening nucleic acid source material for vaccine development
Characterization and QC of small RNA molecules and CRISPR/Cas9 gRNA

For research use only. Not for use in diagnostic procedures.

Revvity is a trademark of Revvity, Inc. All other trademarks are the property of their respective owners.

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Product Variants

Throughput: Low-throughput

Part #:

CLS138162

Throughput: High-throughput

Part #:

CLS137031

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Product information

Overview

Accurate sizing, quantification and quality control of DNA, RNA, and NGS libraries.

The LabChip® GX Touch™ nucleic acid analyzer is a comprehensive solution for genomic sizing and quantitation. It offers:

Quantitation of DNA and RNA sample integrity hours faster than agarose gels
Maximize rare or low-concentration samples like cfDNA, PCR-free libraries, and ChIP-seq libraries
Accurate quantitation down to 25 pg/µL for DNA smears and 0.5 pg/µL for fragments
NGS library prep analysis and QC
Flexible throughput options making it a cost-efficient – 96-well or 384-well (HT) format
Data visualization options (electropherogram, virtual gel, or tabular report)

The LabChip GX Touch nucleic acid analyzer also supports a variety of DNA and RNA analysis, which provides unparallel genomic data quality with minimal input requirements. When the concentrations are low, and samples are precious, The LabChip® DNA High Sens and RNA Pico assays are ideal choice for reliable measurement and sample preservation. With complete analysis of genomic material in about 30 seconds, the LabChip GX Touch nucleic acid analyzer eliminates the nucleic acid quantitation workflow bottleneck. High-resolution analysis provides exact sizing and quantitation of DNA fragments and smears down to 5 bp from samples as small as 2 pg/µL.

The system offers a broad variety of DNA analysis options, including the NGS 3K assay, which provides unparalleled genomic data quality with minimal input requirements. This high degree of sensitivity also makes it the ideal instrument for gDNA and PCR-free DNA quantitation, where concentrations are low, samples are precious, and their preservation is essential.

Coming soon …. Empower on LabChip!

Take full control of your nucleic acid and protein assays on the LabChip GX Touch^™ and LabChip GXII Touch™ systems with Waters Empower™ software. Seamlessly acquire and analyze your data with a single software with the new LabChip™ Empower™ v1.0 driver.

Contact your sales rep using the request more information button above to learn how you can upgrade to the LabChip Empower driver v1.0 and get:

Improved efficiency: By running LabChip systems directly from the Empower software, labs can streamline workflows, reduce hands-on time, and boost productivity.
Data integrity: Ensure your data is securely stored and readily available for review, analysis, and audit through the Empower software’s robust compliance features.
Future-proof: LabChip Empower driver v1.0 is fully compatible with the Empower software, ensuring your system is ready for future software updates and advancements.

Purity and integrity analysis of mRNA-based vaccines

By using LabChip® RNA Assay, researchers at Merck developed an assay to characterize purity and integrity of mRNA vaccines. This fast, easy and efficient workflow helped speed up vaccine development and meet increased manufacturing high volume demand.

The system offers a broad variety of DNA analysis options, including the NGS 3K assay and the cfDNA assay, which provide unparalleled genomic data quality with minimal input requirements. This high degree of sensitivity also makes it the ideal instrument for gDNA, cfDNA, and PCR-free DNA quantitation, where concentrations are low, samples are precious, and their preservation is essential.

Dimensions

Height 69 cm | 27 in
Width 51 cm | 20 in
Depth 49 cm | 19.5 in

Specifications

Physical Specifications

Depth	49.0 cm
Width	51.0 cm

Other Specifications

21CFR Compatible	Yes
Brand	LabChip GX LabChip GXII
Model	LabChip GX Touch HT Nucleic Acid Analyzer
Sample Quantity	384
Throughput	High-throughput

Video gallery

References

Bagheri, H., Friedman, H., Shao, H., Chong, Y., Lo, C., Emran, F., . . . Peterson, A. (2018). TIE: A Method to Electroporate Long DNA Templates into Preimplantation Embryos for CRISPR-Cas9 Gene Editing. The CRISPR Journal,1(3), 223-229. doi:10.1089/crispr.2017.0020.
Chesnais, V., Ott, A., Chaplais, E., Gabillard, S., Pallares, D., Vauloup-Fellous, C., . . . Ginoux, E. (2018). Using massively parallel shotgun sequencing of maternal plasmatic cell-free DNA for cytomegalovirus DNA detection during pregnancy: A proof of concept study. Scientific Reports, 8(1). doi:10.1038/s41598-018-22414-6.
Costa, J-M., et al. (2018). Cell-free fetal DNA versus maternal serum screening for trisomy 21 in pregnant women with and without assisted reproduction technology: a prospective interventional study. Genetics in Medicine. doi:10.1038/gim.2018.4.
Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Berge, M. V., Nawijn, M. C., & Pouwels, S. D. (2018). Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release. Scientific Reports,8(1). doi:10.1038/s41598-018-30602-7.
Ford, L., Carter, G. P., Wang, Q., Seemann, T., Sintchenko, V., Glass, K., . . . Kirk, M. D. (2018). Incorporating Whole-Genome Sequencing into Public Health Surveillance: Lessons from Prospective Sequencing of Salmonella Typhimurium in Australia. Foodborne Pathogens and Disease, 15(3), 161-167. doi:10.1089/fpd.2017.2352.
Gergen, J., Coulon, F., Creneguy, A., Elain-Duret, N., Gutierrez, A., Pinkenburg, O., . . . Haspot, F. (2018). Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene. Plos One, 13(2). doi:10.1371/journal.pone.0192602.
Giand et al. (2021) Early transmission of SARS-CoV-2 in South Africa: An epidemiological and phylogenetic report. International Journal of Infectious Diseases, 103, 234-241, doi.org/10.1016/j.ijid.2020.11.128.
Kim, K.W., et al. (2021) Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing. Sci Rep 11, 3934 doi.org/10.1038/s41598-021-83642-x.
Mogilevsky, M., Shimshon, O., Kumar, S., Mogilevsky, A., Keshet, E., Yavin, E., Heyd, F., and Karni, R. (2018) Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment. Nucleic Acids Res. doi: 10.1093/nar/gky921.
Ong, J., Woldhuis, R. R., Boudewijn, I. M., Berg, A. V., Kluiver, J., Kok, K., . . . Brandsma, C. A. (2019). Age-related gene and miRNA expression changes in airways of healthy individuals. Scientific Reports,9(1). doi:10.1038/s41598-019-39873-0.
Raffaele, J., Loughney, J. W., & Rustandi, R. R. (2021). Development of a microchip capillary electrophoresis method for determination of the purity and integrity of mrna in lipid nanoparticle vaccines. ELECTROPHORESIS. doi.org/10.1002/elps.202100272.
Trolle, C., et al. (2016) Widespread DNA hypomethylation and differential gene expression in Turner syndrome. Scientific Reports (6). doi.org/10.1038/srep34220.