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Cell Lines & Stem Cells

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Efficient cell line development to deliver productive endpoints

Our comprehensive suite of cell lines caters to a wide range of applications, spanning from biologics discovery through preclinical development. Designed to seamlessly align with your research and development needs, our cell lines offer the foundation for your scientific breakthroughs.

Choose from a variety of cell lines, including GPCR cell lines, Luciferase-labeled tumor cell lines, Engineered cell lines, Chosource platform, Membrane preparations.

Our cell lines can be used to identify and characterize biomarkers of interest, while addressing specificity and validation challenges through next-generation platforms.

Cell Lines & Stem Cells

Explore our cell lines & stem cells solutions

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1 - 25 of 542 Products and Services
Receptor cell membranes
Membrane Target Systems: Neurokinin NK3 (human) membrane preparation in CHO-K1 cells, 400 Units

Our Membrane Target Systems: Neurokinin NK3 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-252-M400UA
List price:
USD 1,317.60
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Receptor cell membranes
Membrane Target Systems: Adenosine A3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System: Adenosine A3 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-012-M400UA
List price:
USD 1,296.90
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Receptor cell membranes
Membrane Target Systems: Adrenergic beta 2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Adrenergic beta 2 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-034-M400UA
List price:
USD 1,601.10
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Receptor cell membranes
Membrane Target Systems: Serotonin 5HT3 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Serotonin 5-HT3 receptor, in HEK-293 cells.

Part Number: RBHS3M400UA
List price:
USD 1,335.60
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Receptor cell membranes
Membrane Target Systems: Dopamine D3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Dopamine D3 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-173-M400UA
List price:
USD 1,314.90
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Receptor cell membranes
Membrane Target Systems: Vasopressin V1a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1a receptor, in HEK-293 cells.

Part Number: RBHV1AM400UA
List price:
USD 1,381.50
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Receptor cell membranes
Membrane Target Systems: Muscarinic M5 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Muscarinic M5 receptor, in CHO-K1 cells.

Part Number: RBHM5M400UA
List price:
USD 1,333.80
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Receptor cell membranes
Membrane Target Systems: Opioid Kappa (OP2) (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human opioid kappa (OP2) receptor, 400 units.

Part Number: 6110558400UA
List price:
USD 1,273.50
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Receptor cell membranes
Membrane Target Systems: Serotonin 5HT5a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Serotonin 5-HT5a receptor, in HEK-293 cells.

Part Number: RBHS5AM400UA
List price:
USD 1,336.50
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Receptor cell membranes
Membrane Target Systems: Cannabinoid CB1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Cannabinoid CB1 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-110-M400UA
List price:
USD 1,493.10
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Receptor cell membranes
Membrane Target Systems: Dopamine D1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Dopamine D1 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-172-M400UA
List price:
USD 1,905.30
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Receptor cell membranes
Membrane Target Systems: Muscarinic M2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Muscarinic M2 receptor, in CHO-K1 cells.

Part Number: RBHM2M400UA
List price:
USD 1,330.20
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Receptor cell membranes
Membrane Target Systems: Transporter Norepinephrine (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Transporter Norepinephrine receptor, in MDCK cells.

Part Number: RBHNETM400UA
List price:
USD 1,364.40
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Receptor cell membranes
Membrane Target Systems: Gastric Inhibitory Polypeptide GIP (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Gastric Inhibitory Polypeptide (GIP) receptor, in HEK-293 cells.

Part Number: RBHGIPM400UA
List price:
USD 1,542.60
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Receptor cell membranes
Membrane Target Systems: Angiotensin AT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Angiotensin AT1 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-072-M400UA
List price:
USD 1,386.00
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Receptor cell membranes
Membrane Target Systems: Adenosine A2a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with Adenosine A2a (human) receptor, in HEK-293 cells.

Part Number: RBHA2AM400UA
List price:
USD 1,313.10
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Receptor cell membranes
Membrane Target Systems: Serotonin 5HT-2A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Serotonin 5HT-2A (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-313-M400UA
List price:
USD 1,314.00
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Receptor cell membranes
Membrane Target Systems: Adrenergic alpha 2B (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Adrenergic alpha 2B (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-031-M400UA
List price:
USD 1,494.00
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Receptor cell membranes
Membrane Target Systems: Adrenergic alpha 1A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Adrenergic alpha 1A (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-036-M400UA
List price:
USD 1,313.10
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Receptor cell membranes
Membrane Target Systems: Muscarinic M4 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Muscarinic M4 receptor, in CHO-K1 cells.

Part Number: RBHM4M400UA
List price:
USD 1,305.00
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Receptor cell membranes
Membrane Target Systems: Melanocortin MC4 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Melanocortin MC4 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-191-M400UA
List price:
USD 1,598.40
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Receptor cell membranes
Membrane Target Systems: Histamine H1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Histamine H1 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-390-M400UA
List price:
USD 1,325.70
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Receptor cell membranes
Membrane Target Systems: Melatonin MT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Melatonin MT1 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-620-M400UA
List price:
USD 1,661.40
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Receptor cell membranes
Membrane Target Systems: Serotonin 5HT-2C (e) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Serotonin 5HT-2C (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-315-M400UA
List price:
USD 1,313.10
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Receptor cell membranes
Membrane Target Systems: Melatonin MT2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target Systems: Melatonin MT2 (human) membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Part Number: ES-621-M400UA
List price:
USD 2,283.30
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1 - 18 of 18 Resources
Application Note
Application Note
cAMP AlphaScreen assay: a method for the pharmacological characterization and screening of Gαi coupled receptors in whole cells

G protein-coupled receptors (GPCRs) are a large family of transmembrane receptors that are significant drug targets. They function as enzymes that activate G-proteins. GPCRs couple to three main families of Gα subunits: Gαi/o, Gαs, and Gαq. The coupling specificity depends on the GPCR and its cellular environment. Gαs and Gαi subunits operate through the cAMP pathway, either activating or inhibiting adenylate cyclase, which converts ATP to cAMP. In this application note, the AlphaScreen™-based cAMP detection technology has been used to study Gαi-coupled receptors, specifically the 5-hydroxytryptamine-1A (5-HT1A) serotonergic receptor. The note demonstrates the utility of the AlphaScreen-based cAMP Assay kit for the pharmacological characterization and potential high-throughput screening of Gαi-coupled receptors.

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Application Note
Application Note
cAMP assay provides flexibility and stable pharmacology

G protein-coupled receptors (GPCRs) play a crucial role in various cellular and physiological processes, including cell proliferation, differentiation, neurotransmission, development, and apoptosis. GPCR activity is commonly assessed by measuring levels of intracellular cAMP upon stimulation by agonists. Abnormal GPCR activity is associated with many diseases, including cancer, making GPCRs an important class of pharmaceutical drug targets. Multiple assay formats have been developed to measure the level of cAMP generated, which can determine the pharmacological potency of different agonists and antagonists. The ideal assay is homogeneous, non-radioactive, and allows for sensitive and reproducible detection. AlphaScreen ™ technology provides a quantitative detection of molecules in a homogeneous, no-wash format and can be applied to GPCR research. Download this application note to learn more on the cAMP AlphaScreen assay: Detailed protocol, Data illustrated by graph and tables, Dynamic range description and validation.

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Flyer
Flyer
CD34+ hematopoietic stem cells: Research with confidence

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Application Note
Application Note
Characterizing chemokine receptor inhibitors with AlphaLISA SureFire Ultra, Alpha SureFire Ultra Multiplex and LANCE Ultra cAMP assays

The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by both antibodies and small molecules. CCR7 and CXCR2 receptors, which are expressed in immune cells and are therapeutic targets for disorders like lupus erythematosus, adult leukemia, lymphomas, chronic obstructive pulmonary disease (COPD), and sepsis. AlphaLISA ™ SureFire ® Ultra ™ and Alpha SureFire ® Ultra ™ Multiplex assays are automation-friendly, applicable to both small and large-scale screens, and can assess phosphorylation status in complex matrices. The LANCE Ultra cAMP assay is measures cyclic AMP (cAMP) produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs). This application note demonstrates how the SureFire Ultra and LANCE Ultra cAMP assays can be used for measuring inhibitors to CCR7 and CXCR2 cell surface receptors using a cellular model system where these receptors are overexpressed in CHO cells. The assays were optimized to measure receptor blockage and assayed receptor activity modulation by detecting ERK and AKT phosphorylation status and cAMP modulation. For more details, download the application note!

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Application Note
Application Note
Functional GPCR Studies Using AlphaScreen cAMP Detection Kit

G protein-coupled receptors (GPCRs) are cell surface transmembrane receptors that activate G-proteins. GPCR activity is often assessed by measuring intracellular cAMP levels upon stimulation by agonists. Since GPCRs are important pharmaceutical drug targets, there’s a high demand for methods to detect and quantify cAMP. The ideal assay is homogenous, non-radioactive, and allows for sensitive and reproducible detection of cAMP. The AlphaScreen™ cAMP assay is one such method. It was evaluated for its ability to detect agonist or antagonist-induced cAMP responses in cells expressing either endogenous or recombinant receptors. Read this application note to access detailed data and results on GPCR studies using AlphaScreen cAMP detection kit.

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Brochure
Brochure
GPCRs: the pathway to discovery

G protein coupled-receptors (GPCRs) are one of the most intensively studied drug targets, with up to one-third of all marketed therapeutics acting by binding to GPCRs. Therapies that target GPCRs include both agonist and antagonists that are used in the treatment of disease in nearly every major organ system and hold significance in several therapeutic areas, such as cardiovascular diseases, neurosciences, respiratory diseases, metabolic disorders, oncology, and rare diseases. We know the importance of furthering GPCR research - and we answer the call with application notes, white papers, and end-to-end solutions including reagents, instruments, and tools for all aspects of research into today’s most promising drug target. For research use only. Not for use in diagnostic procedures.

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Application Note
Application Note
Improved deep-tissue imaging with red-shifted luciferase tumor cell lines

The application note demonstrates how our IVISbrite tumor cell lines labeled with red-shifted luciferase (Red F-luc) yields a 100-fold higher signal intensity compared to competitor luciferase labeled cells. The increased brightness of our Red F-luc bioluminescent cells lines enable deeper tissue imaging of tumors. For research use only. Not for use in diagnostic procedures.

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eBook
eBook
In vivo imaging solutions

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 20,000 peer reviewed articles as proof.

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FAQ
FAQ
IVISbrite Tumor cell lines and substrates

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Literature - Publication Review
Literature - Publication Review
Key signaling pathways in liquid cancer: therapeutic targets, screening tools, and future developments

Liquid tumors, which occur in the blood, bone marrow, or lymph nodes, are categorized into three main types of cancer: leukemia, lymphoma, and myeloma. Unlike solid tumors such as carcinomas and sarcomas, these cancers do not form solid masses, leading to different diagnosis and treatment approaches. Leukemia and lymphoma, both forms of blood cancer, affect the body differently. Leukemia primarily impacts the blood and bone marrow, while lymphomas mainly affect the lymph nodes. Significant progress has been made in developing new treatments for both cancers, often targeting the signaling pathways that are constantly activated in specific cancer types. This review highlights some of these signaling pathways and demonstrates how assays based on HTRF and AlphaLISA technologies can be used in the screening and development of new therapies for leukemia and lymphoma treatment.

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Application Note
Application Note
LANCE Ultra cAMP: a new TR-FRET cAMP assay for Gs - and Gi-coupled receptors.

We have developed a second-generation LANCE® time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by activated GPCRs

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Application Note
Application Note
Measuring Performance of an Automated and Miniaturized LANCE Ultra cAMP Assay for the Gi-coupled 5-HT1A Receptor- a Comparative Study

In this note we describe the miniaturization of a LANCE Ultra cAMP assay from 384-to 1,536-well plate format for the identification and characterization of agonists and antagonists of a Gi-coupled GPCR.

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Scientific Poster
Scientific Poster
Novel optical 2D image acquisition and analysis of tumor metastasis using the MVI-2 two-mouse, 360-degree positioning device

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Brochure
Brochure
Radioligand selection guide

Discover a comprehensive collection of GPCR cell lines, membrane preparations, and complementary radioligands designed to drive your GPCR research. Utilize this selection guide to easily identify: Cell lines available for specific receptors Assays that cell lines are validated for Corresponding complementary radioligands and their pharmacological action Learn more about the tools to support your research in this guide!

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Protocol/SOP
Protocol/SOP
SOP: Cell preparation and instructions for in vivo injection of IVISbrite tumor cells

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Protocol/SOP
Protocol/SOP
SOP: IVISbrite LNCaP red F-luc tumor cell culture guidelines

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Protocol/SOP
Protocol/SOP
SOP: IVISbrite tumor cell culture guidelines

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Flyer
Flyer
The 5 most common mistakes to avoid when culturing IVISbrite tumor cells

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