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IVISense Pan Cathepsin 680 Fluorescent Probe (ProSense 680)

IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense Pan Cathepsin 680 Fluorescent Probe (ProSense 680)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes

Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

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Feature Specification
Unit Size 1 vial (10 doses)
Specificity Cathepsin proteases
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Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

View product information
Product variants
Wave Length: 680 nm
Part #:
NEV10003
List price
USD 581.26
Your online price:
Wave Length: 750 nm
Part #:
NEV10001EX
List price
USD 612.39
Your online price:
Wave Length: 750 nm
Style
FAST
Part #:
NEV11171
List price
USD 676.29
Your online price:
For research use only. Not for use in diagnostic procedures.
Total list price:
USD 581.26
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IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense Pan Cathepsin 680 Fluorescent Probe (ProSense 680)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense Pan Cathepsin 680 Fluorescent Probe (ProSense 680)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes

Product information

Overview

IVISense Pan Cathepsin 680 is our original “Smart” cathepsin probe; rather than targeting all protease, smart probes become fluorescent only after enzymatic cleavage, which keeps background down and allows detection of activated protease. 24h imaging at 680 nm.

Specifications

Brand
IVISense
Fluorescent Agent Type
Enzyme activated
Imaging Modality
Fluorescence
Shipping Conditions
Shipped in Blue Ice
Specificity
Cathepsin proteases
Storage Conditions
+2 to +8 °C
Therapeutic Area
Arthritis
Atherosclerosis
Inflammation
Oncology
Pulmonary
Vascular
Unit Size
1 vial (10 doses)
Wave Length
680 nm

Resources

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7-12 of 12 Resources
Application Note Icon
Application Note
Multiplex 2D imaging of NIR molecular imaging agents on the IVIS SpectrumCT platform

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing...

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Application Note
Noninvasive in vivo quantitation of asthma severity using IVISense fluorescent probes

This app note highlights using IVISense Pan Cathepsin 680 NIR fluorescent probe for noninvasive in vivo imaging and quantitation...

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Application Note
Quantitative analysis of 3D microtissue growth and biomarker intensity
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Protocol/SOP
Protocol/SOP
SOP: IVISense Pan Cathepsin 680 (NEV10003) for in vivo imaging
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Whitepaper
Understanding the ‘how’ and ‘why’ of spectral unmixing

In vivo fluorescence imaging displays a very broad utility and has become a well-established modality for functional imaging in...

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Application Note
Visualization of cathepsin activity using IVISense Pan Cathepsin 680 agent from well to cell to animal
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