Pathogen genomics
Genetic information from viruses, bacteria and other infectious organisms plays a crucial role in detetection, investigating outbreaks, describing transmission patterns, monitoring antimicrobial resistance and last but not least, developing interventions such as vaccines.Next-generation-sequencing research has made it possible to investigate pathogens as well as microbiome genomes at much greater detail and throughput.
Genetic information from viruses, bacteria and other infectious organisms plays a crucial role in detetection, investigating outbreaks, describing transmission patterns, monitoring antimicrobial resistance and last but not least, developing interventions such as vaccines.Next-generation-sequencing research has made it possible to investigate pathogens as well as microbiome genomes at much greater detail and throughput.
Host pathogen interactions
Understanding host-pathogen interactions on a molecular, cellular or organism level is the basis for drug discovery. To achieve physiological relevant results, today’s infectious disease research moves towards more complex disease models such as co-cultures or organoids that better resemble in vivo biology. Whether you want to analyze cellular models or in vivo models, or study protein:protein interactions and identify PPI inhibitors, we provide the reagents, instruments and software you need to enable these research applications.
Understanding host-pathogen interactions on a molecular, cellular or organism level is the basis for drug discovery. To achieve physiological relevant results, today’s infectious disease research moves towards more complex disease models such as co-cultures or organoids that better resemble in vivo biology. Whether you want to analyze cellular models or in vivo models, or study protein:protein interactions and identify PPI inhibitors, we provide the reagents, instruments and software you need to enable these research applications.
Immune response
When a pathogen infects the human body, a battle ensues between the host’s innate & adaptive immune systems and the pathogen’s virulence mechanisms and factors. Pathways such as MAP kinase, JAK/STAT, and NFκB play a central role in the antiviral immune response along with ligands such as IL-6, TNFα, and the INFs (-γ, -α, -β, and -λ). We offer a wide range of reagents, detection and imaging instruments enabling to study the antiviral immune response both in vitro and in vivo.
When a pathogen infects the human body, a battle ensues between the host’s innate & adaptive immune systems and the pathogen’s virulence mechanisms and factors. Pathways such as MAP kinase, JAK/STAT, and NFκB play a central role in the antiviral immune response along with ligands such as IL-6, TNFα, and the INFs (-γ, -α, -β, and -λ). We offer a wide range of reagents, detection and imaging instruments enabling to study the antiviral immune response both in vitro and in vivo.
Drug discovery
Antimicrobial research and drug discovery requires sensitive and reliable technologies to detect microbial growth and measure antimicrobial effects. We provide solutions to measure bacterial growth or viral titers, perform target-based, high-throughput drug discovery or phenotypic research and characterize bacterial phenotypes for antimicrobial resistance research using high-content analysis.
Antimicrobial research and drug discovery requires sensitive and reliable technologies to detect microbial growth and measure antimicrobial effects. We provide solutions to measure bacterial growth or viral titers, perform target-based, high-throughput drug discovery or phenotypic research and characterize bacterial phenotypes for antimicrobial resistance research using high-content analysis.
Viral diseases and vaccines
Continued discovery of new antiviral medications and vaccines is important for global human health, particularly as new viruses, like we saw with COVID-19 or novel Influenza viruses, can emerge quickly. We offer solutions for measuring virus neutralization, antiviral compound effects, antiviral immune response or for studying cytokine storm, which is associated with COVID-19.
Continued discovery of new antiviral medications and vaccines is important for global human health, particularly as new viruses, like we saw with COVID-19 or novel Influenza viruses, can emerge quickly. We offer solutions for measuring virus neutralization, antiviral compound effects, antiviral immune response or for studying cytokine storm, which is associated with COVID-19.
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