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Scientific Poster
rAAV Manufacturing Optimization Using Design of Experiments
Explore the use of design of experiments (DoE) for optimizing plasmid ratios in rAAV manufacturing, improving yields and reducing production costs.
Scientific Poster
Image-Based CAR-T Cell Assays for Apoptosis and CAR Expression Monitoring
This poster introduces a new image-based method to monitor CAR expression and apoptosis in CAR-T cells, offering insights into cell viability post-gene delivery.
Whitepaper
ImmuSignature™ MLR: Rapid high-throughput assessment of therapeutic immunogenicity
This white paper describes how a rapid immunogenicity assessment screening can provide invaluable support for IND applications.
Literature - Publication Review
The future of immunotherapy gets brighter with base editing
This literature review discusses how base editing technology addresses the shortcomings of other gene editing technologies for immunotherapy.
Whitepaper
Assessing the epigenetics of T cell exhaustion using CRISPR screens
Explore the epigenetics of T cell exhaustion and practical techniques to assess immune cell epigenetic regulators using CRISPR screens.
Whitepaper
Base editing and stem-cell based therapies
This white paper explores how base editing is advancing iPSCs in the fields of basic science, regenerative medicine and immunotherapy.
Whitepaper
Addressing the challenges in solid tumor therapy with base editing
Read this white paper to learn about how base editing is helping to address key challenges in immunotherapies for solid tumors.
Scientific Poster
A single-step process for engineering hypoimmunogenic pluripotent stem cells with the Pin-point™ platform
Learn about the utility of the Pin-point™ base editing platform for the engineering of allogeneic PSCs.
Webinar
wbs-strategies-for-therapeutic-screening-in-immune-cells
This on-demand webinar provides an overview into how integrating immune cell screening into drug discovery pipelines can provide insight into the immunogenicity of individuals and help to quickly characterize them.
Application Note
Rapid screening of novel therapeutics by ImmuSignature™ T cell activation assay
This application note describes the development of a robust T cell activation assay to assess the impact of novel therapeutics on T cell function.
Scientific Poster
Interchanging Cas enzymes, deaminases, and aptamerguide RNA combinations to achieve optimal editing with the modular Pin-point™ base editing platform
Learn how to apply multiplex base editing to efficiently develop engineered CAR-T cells and hypoimmunogenic iPSCs.
Application Note
Base editing with nuclease flexibility
In this application note, we demonstrate how the Pin-point™ base editing platform’s modularity allows for its components to be optimized to the target site.
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