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Tyrosinemia Monitoring
| Test Code | B0022 |
|---|---|
| Test Summary |
This test measures succinylacetone and tryosine to aid in monitoring of tyrosinemia. |
| Turn Around Time | 3 days |
| Acceptable Sample Types | Dried Blood Spots |
| Acceptable Billing Types | Institutional Billing , Self (patient) Payment |
| NY Approved | Yes |
| Self (patient) Price | $108.90 |
| Institutional Price | $108.90 |
**The CPT codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association, and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party.
This testing service has not been cleared or approved by the U.S. Food and Drug Administration. Testing services may not be licensed in accordance with the laws in all countries. The availability of specific test offerings is dependent upon laboratory location.
Indications for Testing
This test is indicated for individuals with tyrosinemia, on treatment, who are being monitored by their healthcare provider.
Condition Description
Tyrosinemia is an inherited metabolic condition in which the body does not have the enzyme FAH needed to metabolize tyrosine. In untreated, tyrosine and its byproducts build up in tissues and organs which can lead to serious health problems. Treatment consists of a diet modifications and the use of a drug that prevents the formation of succinylacetone, the toxic agent responsible for liver and kidney damage. For patients with tyrosinemia, frequent monitoring of tyrosine and succinylacetone levels can aid in maintaining the correct dose of medication and monitoring of metabolite levels within the body.
Test Methods and Limitations
Tandem mass spectrometry (MS/MS) is an analysis technique that utilizes two mass analyzers to target analytes based on mass and charge. This mass filtering process provides highly sensitive and specific measurements of small molecules or peptides from biological samples.
Detailed Sample Requirements
Dried Blood Spots
| Collection Container(s) | Dried blood spot card |
|---|---|
| Collection | Follow kit instructions. Briefly, allow blood to saturate the card until indicated areas are filled and blood has soaked through the card. Air dry the card at ambient temperature for at least 3 hours.
|
| Sample Condition | Follow the instructions provided with the collection set. Store the dried blood at ambient temperature for up to two days. If the specimen cannot be sent as soon as it is dry, the filter paper should be placed in a sealable plastic bag and stored in a refrigerator (≤ 8°C) or preferably in a freezer. |
| Shipping | Follow kit instructions. Double bag and ship overnight at ambient temperature. |