This test analyzes genes associated with macular dystrophy, including Stargardt disease.
Test Code | D4305F |
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Test Summary |
This test analyzes genes associated with macular dystrophy, including Stargardt disease. |
Turn Around Time | 7 - 10 days |
Acceptable Sample Types | DNA, Isolated , Dried Blood Spots , Saliva , Whole Blood (EDTA) |
Acceptable Billing Types | Institutional Billing , Self (patient) Payment |
NY Approved | No |
CPT Codes** | 81479(x1), 81443(x1) |
Self (patient) Price | $900.00 |
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Institutional Price | $1,350.00 |
Macular dystrophy refers to a group of genetic disorders that result in progressive degeneration of the macula, which results in progressive vision loss. This condition typically affects both eyes and can manifest in various forms. Pattern dystrophy is characterized by the accumulation of irregular patterns of yellowish deposits (called drusen) in the macula, leading to distorted vision. Stargardt disease, or juvenile macular degeneration, begins in childhood or adolescence and results in progressive vision loss due to the buildup of lipofuscin, a fatty substance, in the retinal pigment epithelium. Cone-rod dystrophy affects the cone and rod photoreceptor cells in the retina, impairing color perception, central vision, and night vision. Vitelliform macular dystrophy, or Best disease, is characterized by the formation of a yellowish egg-shaped lesion in the macula, leading to progressive central vision loss.
Collection |
Required DNA Quantity by Test Type*:
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Sample Condition |
* Required DNA Quality: High molecular weight DNA (>12kb). A260/A280 reading should be ≥ 1.8. A260/230 a ratio range of 1.8 to 2.2. Contact the laboratory for specific amounts if total ng cannot be met. |
Shipping |
Ship overnight at ambient temperature. |
SPECIAL SAMPLE INSTRUCTIONS |
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Collection Container(s) |
EDTA (purple top) |
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Collection |
Infants (< 2-years): 2 to 3 mL; Children (>2-years): 3 to 5 mL; Older children and adults: Minimum 5mL. The blood tube should be inverted several times immediately after blood collection to prevent coagulation. |
Sample Condition |
Store at ambient temperature. Do not refrigerate or freeze. |
Shipping |
Ship overnight at ambient temperature ensuring receipt within 5-days of collection. |
SPECIAL SAMPLE INSTRUCTIONS |
Clotted or hemolyzed samples are not accepted. |
Collection Container(s) |
Oragene™ Saliva Collection Kit or ORAcollect-Dx kit |
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Collection |
Collect saliva on an Oragene™ Saliva Collection Kit ORAcollect-Dx kit according to the manufacturer's instructions. |
Sample Condition |
Store at ambient temperature. Do not refrigerate or freeze. |
Shipping |
Ship overnight at ambient temperature. |
SPECIAL SAMPLE INSTRUCTIONS |
Please contact Revvity Omics to request the saliva collection kit for patients who cannot provide a blood sample as whole blood is the preferred sample. Testing using Saliva swabs is currently not available for customers in India. Contact the Revvity Omics laboratory for more information. |
Collection Container(s) |
Dried blood spot card |
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Collection |
Follow kit instructions. Briefly, allow blood to saturate the card until indicated areas are filled and blood has soaked through the card. Air dry the card at ambient temperature for at least 3 hours.
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Sample Condition |
Follow the instructions provided with the collection set. Store the dried blood at ambient temperature for up to two days. If the specimen cannot be sent as soon as it is dry, the filter paper should be placed in a sealable plastic bag and stored in a refrigerator (≤ 8°C) or preferably in a freezer. |
Shipping |
Follow kit instructions. Double bag and ship overnight at ambient temperature. |
Select the correct test for your patient, and download and fill out the Clinical Genomics test requisition form.
Obtain a sample for testing from the patient using one of the provided Revvity Omics test packs.
Send samples and all required forms back to Revvity for processing using pre-paid shipping label.
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