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Duchenne Muscular Dystrophy Creatine Kinase Activity
| Test Code | B0006 |
|---|---|
| Test Summary |
This biochemial test measues the level of creatine kinase. |
| Turn Around Time | 3 days |
| Acceptable Sample Types | Dried Blood Spots |
| Acceptable Billing Types | Institutional Billing , Self (patient) Payment |
| NY Approved | Yes |
| Self (patient) Price | $66.00 |
| Institutional Price | $66.00 |
**The CPT codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association, and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party.
This testing service has not been cleared or approved by the U.S. Food and Drug Administration. Testing services may not be licensed in accordance with the laws in all countries. The availability of specific test offerings is dependent upon laboratory location.
Test Description
This test measures creatine kinase activity, which can be elevated in patients with Duchenne muscular dystrophy (DMD).
Indications for Testing
- Individuals with a clinical suspicion of DMD.
- Individuals with a family history of DMD
Condition Description
Duchenne muscular dystrophy (DMD) is a inherited muscular dystrophy. DMD usually presents in early childhood with delayed motor milestones. Proximal weakness causes a waddling gait and difficulty climbing stairs, running, jumping and standing up from a squatting position. DMD is progressive with affected children being wheelchair dependent by age 12. Cardiomyopathy occurs in almost all individuals with DMD after age 18. DMD in in herited in an X linked manner. (NCBI, genereviews)
Test Methods and Limitations
Fluoroimmunometric assay based on the direct sandwich technique in which two antibodies are directed against a given analyte. Calibrators and serum samples, containing the analyte are reacted with immobilized monoclonal antibodies directed against the analyte. Europium-labeled monoclonal antibodies directed against an antigenic site on the analyte are reacted with the analyte bound to the solid-phase antibody. The Inducer dissociates europium ions from the labeled antibodies into the solution where they form highly fluorescent chelates with components of the Inducer. The fluorescence in each cup is then measured. The europium fluorescence from each sample is proportional to the concentration of analyte in the sample.
Detailed Sample Requirements
Dried Blood Spots
| Collection Container(s) | Dried blood spot card |
|---|---|
| Collection | Follow kit instructions. Briefly, allow blood to saturate the card until indicated areas are filled and blood has soaked through the card. Air dry the card at ambient temperature for at least 3 hours.
|
| Sample Condition | Follow the instructions provided with the collection set. Store the dried blood at ambient temperature for up to two days. If the specimen cannot be sent as soon as it is dry, the filter paper should be placed in a sealable plastic bag and stored in a refrigerator (≤ 8°C) or preferably in a freezer. |
| Shipping | Follow kit instructions. Double bag and ship overnight at ambient temperature. |