Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.
- High specific activity: The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
- High purity: We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
- High selectivity: Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
- Validated for receptor binding: all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.
For research use only. Not for use in diagnostic procedures.
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DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bind the mu opioid receptor as well.
Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6).
(-)-CGP-12177 radioligand tritiated at the 5,7 position. CGP-12177 acts as an antagonist at the β1- and β2-adrenoceptors and a partial agonist at β3-adrenoceptors.
Oxytocin, tritiated on the tyrosyl group. Oxytocin is a neurotransmitter that binds and activates oxytocin receptors.
Caffeine, radiolabeled with C-14 at the 1-methyl position. Caffeine acts as a non-selective antagonist at adenosine receptors.
Naloxone radioligand tritiated at the 2,3 position. Naloxone acts as a non-selective, competitive opioid receptor antagonist.
Mesulergine, tritiated on the N-methyl group. Mesulergine acts as an antagonist at serotonin 5-HT2A and 5-HT2C receptors, and as a partial agonist at dopamine receptors.
cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.
Nitrendipine, tritiated on the 5-methyl group. Nitrendipine is a dihydropyridine calcium channel blocker.
AFDX-384 (BIBN-161) radioligand tritiated at the 2,3-dipropylamino position. AFDX-384 acts as a selective antagonist of muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes.
Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Strychnine, tritiated on the benzene ring. Strychnine acts as an antagonist at glycine and acetylcholine receptors.
3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors. This product has a scheduled lot release for the second Monday in February and August. NOTE: NET574001MC will be obsolete soon.
5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.
Flunitrazepam (Rohypnol), tritiated on the methyl group. Flunitrazepam is a benzodiazepine and acts as an agonist at GABAA (γ-aminobutyric acid) receptors.
5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
AH5183 (vesamicol) radioligand tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.
L-propranolol, tritiated at the 4 position. Propranolol is a non-selective beta blocker that acts as a potent antagonist for β-adrenoceptors.
CCK-8, tritiated at the propionyl position. Sulphated CCK8 is a peptide hormone that can bind both cholecystokinin B and cholecystokinin A receptors.
Diprenorphine (Revivon; M5050; diprenorfin), tritiated at the 15,16- position. Diprenorphine acts as a non-selective antagonist at opioid receptors.
Rauwolscine, tritiated on the methyl group. Rauwolscine acts as an antagonist at α2-adrenergic receptors.
Imipramine hydrochloride, tritiated on the benzene ring. Imipramine is believed to act as an antagonist at certain serotonin, histamine, and cholinergic receptors.
Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.