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Application Note
Using IP1 assays to study FGFR mediated pathways for cancer drug research
Detection of IP1 accumulation was achieved using either a no wash Revvity HTRF or AlphaLISA kits. These assays enable the rapid and accurate measurement of the activation status of intracellular downstream key enzymes and second messengers
Application Note
Simultaneous detection of drug efficacy and toxicity by combining HTRF, AlphaLISA, or AlphaLISA SureFire Ultra with ATPlite
This application note demonstrates how compound’s mechanism of action and potential cytotoxic effects can be deciphered thanks to the combination of AlphaLISA™, HTRF™ or AlphaLISA™ SureFire® Ultra™ immunoassays with ATPlite™ 1step cell viability assay.
Application Note
No-Wash IP1 assays are a powerful readout to characterize compounds modulating the FGFR signaling pathway in cancer drug research
This application note demonstrates that detecting the intracellular accumulation of IP1, mediated by FGFR-dependent activation of PLCγ1, can be a powerful alternative for characterizing compounds that modulate FGFR signaling in various cancer cell lines expressing FGFR1, FGFR2, and FGFR3.
Application Note
Orthogonal validation of CRISPRCas9 and siRNA generated phenotypes using cell painting
Investigate cell cycle regulation through AURKB, GMNN, and PLK1 proteins. Learn how CRISPR-Cas9 and siRNA techniques, combined with high-content imaging on the Opera Phenix™ Plus, reveal their roles in cell division and genomic stability.
Application Note
Evaluation of drug selectivity and efficacy using PROTACs in a 3D co-culture spheroid model
The aim of this study was to evaluate the efficacy and selectivity of SJF1528, a pan-EGFR PROTAC, and MS39, a mutant-specific EGFR L858R PROTAC, while exploring the use of both high-content imaging and no-wash HTRF immunoassays in encapsulated 3D spheroid models.
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