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Application Note
Development of pharmacokinetic (PK) assays for detecting biosimilars targeting TNF alpha using AlphaLISA
In this Application Note, AlphaLISA™ assays are used for detecting biosimilars targeting TNF alpha. Learn more.
Application Note
Monitoring residual HEK293 DNA in AAV-based therapies using the HostDetect HEK293 PCR DNA quant kit
Data behind the development of the HostDetect Hek293 kit that offers a PCR-based approach for quantifying residual host cell DNA
Application Note
Biochemical binding ADCC assays utilizing AlphaLISA toolbox reagents for the characterization of hIgGs and FcγR1A
In this application note we demonstrate the ease with which AlphaLISA toolbox reagents can be used to develop any FcγR binding assay across the various stages of biologics research and development, including therapeutic screening and GMP Lot Release.
Application Note
A fast and simple chemiluminescent assay for monitoring of DNA-protein interactions
In this application note, we use HepG2 nuclear extracts to demonstrate the binding of Sp1 and HNF1 transcription factors to tagged oligonucleotides containing required cognate response elements. Read this note to see the results and access detailed data compared to EMSA.
Application Note
FcRn binding assays using AlphaLISA and HTRF technologies
In this application note you will find information about how both AlphaLISA™ and HTRF™ assays can help to measure the relative affinities of therapeutic antibodies to FcRn.
Application Note
Importance of accurate cell counting for single cell sequencing platforms using the Cellometer K2 fluorescent viability cell counter
Application note describing accurate cell counting for single cell sequencing platforms using the Cellometer K2 fluorescent cell counter.
Application Note
Functional GPCR Studies Using AlphaScreen cAMP Detection Kit
Read this application note to access detailed data and results on GPCR studies using AlphaScreen cAMP detection kit
Application Note
A novel method for T-cell immunophenotyping using the Cellometer Spectrum image cytometer.
Application note describing a novel method for T-cell immunophenotyping using the Cellometer Spectrum image cytometer.
Application Note
A comparative study of two immunoassay platforms to determine lentivirus titer for CAR-T development
This application note demonstrates a comparative quantification of the p24 titer in a lentiviral GFP control sample using Alliance HIV-1 p24 Antigen ELISA and p24 AlphaLISA immunoassay platforms.
Application Note
cAMP assay provides flexibility and stable pharmacology
AlphaScreen™ technology provides a quantitative detection of molecules in a homogeneous, no-wash format and can be applied to GPCR research.
Application Note
Evaluating the specificity of PD-1 and PD-L1 blocking antibodies using AlphaLISA human and mouse PD-1/PD-L1 binding kits
Find out how the AlphaLISA human/mouse PD-1/PD-L1 binding assays provide a fast, powerful, homogeneous platform for obtain binding potencies from potential novel drug candidates.
Application Note
Utilization of AlphaLISA technology to accurately detect asthma biomarkers in human serum
In this application note, AlphaLISA technology was used to quantify biomarker levels in serum samples, specifically Human IL-21, IL-33, and TNFα.
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