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Rauwolscine, [Methyl-3H]-, 250µCi (9.25MBq)

Rauwolscine, tritiated on the methyl group. Rauwolscine acts as an antagonist at α2-adrenergic receptors.

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HELLO10
Feature Specification
Concentration 1 mCi/ml
Label Position Specifically Labeled
Molecular Weight 354.4
Receptor Adrenoceptors

Rauwolscine, tritiated on the methyl group. Rauwolscine acts as an antagonist at α2-adrenergic receptors.

Click to copy promo code to clipboard.
Save 10% on your first Revvity.com order. Use promo code below.
HELLO10
Product Variant
Unit Size: 250 µCi
Part #:
NET722250UC
List Price
USD 3,494.00
For research use only. Not for use in diagnostic procedures.

Overview

Rauwolscine acts as an α2-adrenergic receptor antagonist.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET722:

  1. T. Nakagawa, K. Nagayasu, N. Nishitani, H. Shirakawa, K. Sekiguchi, Y. Ikarashi, Y. Kase, S. Kaneko, Yokukansan inhibits morphine tolerance and physical dependence in mice: The role of α2A-adrenoceptor, Neuroscience, Volume 227, 2012, Pages 336-349.
  2. Ignacio Javier Chiesa, Lilian Fedra Castillo, Isabel Alicia Lüthy, Contribution of α2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells, The Journal of Steroid Biochemistry and Molecular Biology, Volume 110, Issues 1–2, 2008, Pages 170-175.

Specifications

Concentration
1 mCi/ml
Molecular Weight
354.4
Specific Activity
>70 Ci/mmol (>2590 GBq/mmol)
CAS Number
131-03-3
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Ethanol solution containing 0.25% ascorbic acid
Detection Modality
Radiometric
Label Position
Specifically Labeled
Molecular Formula
C21H26N2O3
Packaging
NENSure vial
Radioisotope
3H
Receptor
Adrenoceptors
Shipping Information
Shipped in dry ice
Shipping Conditions
Shipped in Dry Ice
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
-80°C
Therapeutic Area
Cardiovascular
Unit Size
250 µCi

Resources

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