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Pancreatic Polypeptide (human), [125I], 10µCi

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.

For research use only. Not for use in diagnostic procedures.

Feature Specification
Fresh Lot Days Fourth Monday of each month
Label Position Nominally Labeled
Molecular Weight 4179
Receptor Neuropeptide Y

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.

For research use only. Not for use in diagnostic procedures.

Product Variants
Unit Size: 10 µCi
Part #:
NEX315010UC
List Price
USD 1,815.00
Unit Size: 50 µCi
Part #:
NEX315050UC
List Price
USD 6,265.00

Overview

10 µCiQuantities of Pancreatic Polypeptide (human), [125I] are available for your research.

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX315:

  1. Sejling, AS., Lange, K.H.W., Frandsen, C.S. et al. (2015), Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes, Diabetologia 58: 1898-1906.
  2. Dirksen, C., Jørgensen, N.B., Bojsen-Møller, K.N., Kielgast, U., Jacobsen, S.H., Clausen, T.R., Worm, D., Hartmann, B., Rehfeld, J.F., Damgaard, M., Madsen, J.L., Madsbad, S., Holst, J.J., Hansen, D.L. (2013), Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obes, 37 (11): 1452-1459.

Specifications

Molecular Weight
4179
Specific Activity
2200.0 Ci/mmol
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer/Solvent
Lyophilized
Detection Modality
Radiometric
Fresh Lot Days
Fourth Monday of each month
Host Species
Human
Label Position
Nominally Labeled
Packaging
NENSure vial
Radioisotope
125I
Receptor
Neuropeptide Y
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
4°C
Therapeutic Area
CNS & Neurologic
Gastrointestinal
Metabolic Disorders
Unit Size
10 µCi

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