LANCE® Eu-labeled anti-c-myc antibodies are purified mouse IgG1 monoclonal antibodies, which recognize the epitope sequence (EQKLISEEDL) derived from the human c-myc protein. These monoclonal antibodies against the c-myc epitope do not cross react with other cellular proteins.

LANCE® (Lanthanide chelate excite) and LANCE® Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One molecule of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore [ULight™ dye, allophycocyanin (APC), etc.]. Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light at 665 nm (for ULight dye and APC).