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IVISense MMP 750 FAST Fluorescent Probe (MMPSense)

Name: IVISense MMP 750 FAST Fluorescent Probe (MMPSense)
Price: 702.04 USD
Availability: InStock

Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.

Revvity’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.

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Feature	Specification
Unit Size	1 vial (10 doses)
Specificity	Matrix Metalloprotease

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Product variants

Wave Length: 645 nm

Part #:

NEV10100

List price

USD 706.60

Your online price:

Wave Length: 680 nm

Part #:

NEV10126

List price

USD 702.04

Your online price:

Wave Length: 750 nm

Part #:

NEV10168

List price

USD 702.04

Your online price:

For research use only. Not for use in diagnostic procedures.

Total list price:

USD 702.04

Product information

Overview

IVISense MMP 750 FAST is excited by 749 nm excitation light, and emits at 775 nm. MMP 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that allows for an earlier optimal imaging window of 12-24 hours after injection, facilitating detection of MMP activity changes in acute models of inflammation or stroke. In addition, the 750 nm wavelength is optimal for minimizing the impact of autofluorescence and chow-related fluorescence that can interfere with image quality. Including IVISense MMP 750 FAST in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.

Specifications

Other specifications

Brand	IVISense
Fluorescent Agent Type	Enzyme activated
Imaging Modality	Fluorescence
Shipping Conditions	Shipped in Blue Ice
Specificity	Matrix Metalloprotease
Storage Conditions	-30 to -16 °C
Therapeutic Area	Arthritis Atherosclerosis Cardiovascular Inflammation Oncology Pulmonary Vascular
Unit Size	1 vial (10 doses)
Wave Length	750 nm

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Whitepaper

Understanding the ‘how’ and ‘why’ of spectral unmixing

In vivo fluorescence imaging displays a very broad utility and has become a well-established modality for functional imaging in...

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