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IVISbrite Staphylococcus aureus Xen40 Bioluminescent Bacterial Strain
IVISbrite Staphylococcus aureus Xen40 Bioluminescent Bacterial Strain
IVISbrite™ Staphylococcus aureus Xen40 bioluminescent pathogenic bacteria was derived from the parental strain UAMS-1. For in vitro or in vivo imaging applications, IVISbrite S. aureus-Xen40 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
For research use only. Not for use in diagnostic procedures.
| Feature | Specification |
|---|---|
| Type | Gram positive |
| Luciferase Classification | Bacterial luciferase (Photorhabdus luminescens lux operon on the bacterial chromosome) |
IVISbrite™ Staphylococcus aureus Xen40 bioluminescent pathogenic bacteria was derived from the parental strain UAMS-1. For in vitro or in vivo imaging applications, IVISbrite S. aureus-Xen40 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
For research use only. Not for use in diagnostic procedures.
IVISbrite Staphylococcus aureus Xen40 Bioluminescent Bacterial Strain
IVISbrite Staphylococcus aureus Xen40 Bioluminescent Bacterial Strain
Product information
Overview
Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. Our bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.
- Engineered Bacterium: Staphylococcus aureus - Xen40
- Parental Strain: UAMS-1
- In Vitro/Ex Vivo: Growth profiles, Catheter model
- In Vivo: Biofilm
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:
- Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
- Sensitivity - subtle changes in cellular viability are rapidly detected
- Inexpensive - no additional substrates needed for bacterial assays
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:
- Rapid identification of lead drug candidates
- Real-time efficacy data
- May help to decrease drug failure by allowing disease relapse to be monitored in the same animal
Specifications
| Brand |
IVISbrite
|
|---|---|
| Imaging Modality |
Bioluminenscence
|
| Luciferase Classification |
Bacterial luciferase (Photorhabdus luminescens lux operon on the bacterial chromosome)
|
| Shipping Conditions |
Shipped Ambient
|
| Storage Conditions |
Requires transfer to cryogenic vial prior to storage.
|
| Therapeutic Area |
Infectious Diseases
|
| Type |
Gram positive
|
| Unit Size |
1 agar plate
|
Resources
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Bacteria growth preparation guidelines using Revvity's IVISbrite™ lux operon labeled bioluminescent bacteria designed for in vivo...
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