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IVISbrite Pseudomonas aeruginosa Xen05 Bioluminescent Bacterial Strain
IVISbrite Pseudomonas aeruginosa Xen05 Bioluminescent Bacterial Strain
IVISbrite™ Pseudomonas aeruginosa Xen05 bioluminescent bacteria was derived from a human septicemia isolate from the American Type Culture Collection (ATCC), used under license. For in vitro or in vivo imaging applications, IVISbrite P. aeruginosa-Xen05 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
For research use only. Not for use in diagnostic procedures.
| Feature | Specification |
|---|---|
| Type | Gram negative |
| Luciferase Classification | Bacterial luciferase (Photorhabdus luminescens lux operon on the bacterial chromosome) |
IVISbrite™ Pseudomonas aeruginosa Xen05 bioluminescent bacteria was derived from a human septicemia isolate from the American Type Culture Collection (ATCC), used under license. For in vitro or in vivo imaging applications, IVISbrite P. aeruginosa-Xen05 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
For research use only. Not for use in diagnostic procedures.
IVISbrite Pseudomonas aeruginosa Xen05 Bioluminescent Bacterial Strain
IVISbrite Pseudomonas aeruginosa Xen05 Bioluminescent Bacterial Strain
Product information
Overview
Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. Revvity's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.
- Engineered Bacterium: Pseudomonas aeruginosa - Xen05
- Parental Strain: Human septicemia isolate**
- In Vitro/Ex Vivo: Growth, Biochemical & Antibiogram profiles, Catheter model
- In Vivo: Sepsis, Pneumonia, Soft tissue & Biofilm models
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:
- Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
- Sensitivity - subtle changes in cellular viability are rapidly detected
- Inexpensive - no additional substrates needed for bacterial assays
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:
- Rapid identification of lead drug candidates
- Real-time efficacy data
- May help to decrease drug failure by allowing disease relapse to be monitored in the same animal
Specifications
| Brand |
IVISbrite
|
|---|---|
| Imaging Modality |
Bioluminenscence
|
| Luciferase Classification |
Bacterial luciferase (Photorhabdus luminescens lux operon on the bacterial chromosome)
|
| Shipping Conditions |
Shipped Ambient
|
| Storage Conditions |
Requires transfer to cryogenic vial prior to storage.
|
| Therapeutic Area |
Infectious Diseases
|
| Type |
Gram negative
|
| Unit Size |
1 agar plate
|
Resources
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Bacteria growth preparation guidelines using Revvity's IVISbrite™ lux operon labeled bioluminescent bacteria designed for in vivo...
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