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IVISbrite 4T1 Red F-luc-GFP Bioluminescent Tumor Cell line (Bioware Brite)

The IVISbrite™ 4T1 Red F-luc-GFP tumor cell line (Bioware® Brite 4T1-Red-FLuc-GFP) is a light-producing and fluorescent cell line derived from 4T1 mouse mammary gland adenocarcinoma. The cells have been stably transduced with the red-shifted firefly luciferase gene from Luciola Italica (Red F-luc) fused to GFP (Green Fluorescent Protein), for a brighter, red-shifted bioluminescent or green fluorescent signal.

Feature Specification
Type Luciola italica Red F-luc, Green Fluorescent Protein (GFP)
Unit Size 2 vials each containing 1 million cells
Luciferase Classification Firefly
Therapeutic Area Oncology

The IVISbrite™ 4T1 Red F-luc-GFP tumor cell line (Bioware® Brite 4T1-Red-FLuc-GFP) is a light-producing and fluorescent cell line derived from 4T1 mouse mammary gland adenocarcinoma. The cells have been stably transduced with the red-shifted firefly luciferase gene from Luciola Italica (Red F-luc) fused to GFP (Green Fluorescent Protein), for a brighter, red-shifted bioluminescent or green fluorescent signal.

Product Variant
Cancer Model: Breast
Part #:
BW128090
For research use only. Not for use in diagnostic procedures.
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Overview

IVISbrite 4T1 Red F-luc-GFP Bioluminescent Tumor Cell line

This cell line has very bright bioluminescence, emitting at least 15,000 photons/cell/sec in vitro. The exact number will vary depending on imaging and culturing conditions.

We recommend using this line in Nude and SCID mouse models. An immune response may occur in Balb/c mice.

By emitting intensified, longer wavelength light that is significantly brighter than other firefly luciferases, our bioluminescent oncology cell lines allow you to visualize and monitor the growth of deep tissue tumors in vivo. The GFP fusion also allows for fluorescent imaging in vivo or ex vivo.

After the cells are injected into an appropriate mouse model, the optimized Red F-luc luciferase enables more sensitive in vivo optical detection with less tissue attenuation so you can detect tumor development earlier, and monitor tumor growth and metastases in both subcutaneous and orthotopic models.

  • Organism: Mouse
  • Tissue: Mammary Gland
  • Disease: Adenocarcinoma
  • Dual Optical Reporters: Red F-luc and GFP

Specifications

Brand
IVISbrite
Cancer Model
Breast
Imaging Modality
Bioluminenscence
Luciferase Classification
Firefly
Shipping Conditions
Shipped in Dry Ice
Storage Conditions
Liquid nitrogen tank
Therapeutic Area
Oncology
Type
<em>Luciola italica</em> Red F-luc, Green Fluorescent Protein (GFP)
Unit Size
2 vials each containing 1 million cells

Resources

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1-6 of 6 Resources
Application Note Icon
Application Note
Improved deep-tissue imaging with red-shifted luciferase tumor cell lines

The application note demonstrates how our IVISbrite tumor cell lines labeled with red-shifted luciferase (Red F-luc) yields a 100...

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eBook
In vivo imaging solutions

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and...

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FAQ
IVISbrite Tumor cell lines and substrates
Protocol/SOP
Protocol/SOP
SOP: Cell preparation and instructions for in vivo injection of IVISbrite tumor cells
Protocol/SOP
Protocol/SOP
SOP: IVISbrite tumor cell culture guidelines
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Flyer
The 5 most common mistakes to avoid when culturing IVISbrite tumor cells

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