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Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[1-14C]-, 250 µCi (9.25 MBq)

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.

For research use only. Not for use in diagnostic procedures.

Product Variants
Part number: NEC855050UC
Unit Size: 50 µCi
List price: USD 1,351.00
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USD 0.00
USD 1,351.00 /each
Part number: NEC855250UC
Unit Size: 250 µCi
List price: USD 7,144.00
Your price: Login to view
USD 7,144.00
USD 7,144.00 /each

Overview

250 µCi quantity of 5-Hydroxytryptamine (5-HT) which binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

Specifications

Concentration
0.1 mCi/ml
Molecular Weight
266.25
Application
Drug Discovery & Development
Brand
NEN Radiochemicals
Buffer
Ethanol : water (2:98)
Detection Method
Radiometric
Label Position
Specifically Labeled
Packaging
NENSure vial
Radioisotope
14C
Receptor Type
5-Hydroxytryptamine
Shipping Conditions
Shipped Ambient
Special Ordering Information
This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions
5°C
Therapeutic Area
Cardiovascular
CNS & Neurologic
Unit Size
250 µCi

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