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GSP Neonatal Phenylalanine kit
Phenylketonuria (PKU) is a disorder of amino acid metabolism with reported incidence ranging from 1 in 19,000 to 1 in 13,500 newborn infants*. It is caused by an inability to convert phenylalanine to tyrosine due to deficient activity of the enzyme, phenylalanine hydroxylase.
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Product information
Overview
As a result, excessive amounts of phenylalanine and toxic metabolites accumulate, harming brain development. The symptoms can be clearly reduced with a diet low in phenylalanine, and early detection is critical in starting the treatment and ensuring normal brain development.
* Kaye CI. and the Committee on Genetics (2006) Newborn Screening Fact Sheets. Pediatrics 118 (3).
GSP Neonatal Phenylalanine - the automated enzymatic assay
The GSP Neonatal Phenylalanine (Phe) kit is intended for the quantitative determination of phenylalanine concentrations in blood specimens dried on filter paper as an aid in screening newborns for phenylketonuria by using the GSP® instrument.
- Automated assay
- Incubation time only 2 x 1h
- Improved precision and performance compared to manual assays
- Contains reagents for 1152 tests (12 plates), clear microplates, U-bottomed, should be ordered separately in a bulk pack of 100.
- 5760 tests (60 plates) product version also available (product no 3308-001B)
- Calibrators and controls are in cassette format
Specifications
| Application |
Newborn Screening
|
|---|---|
| Assay Technology |
Enzymatic
|
| Brand |
GSP®
|
| Calibration Standards |
Yes
|
| Detection Method |
Enzymatic
|
| Disorders |
Phenylketonuria
|
| Sample Type |
Dried blood spots
|
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