GR125743 acts as an antagonist at serotonin 5-HT_1B and 5-HT_1D receptors. These receptors belong to a class of serotonin GPCRs and are potential drug targets for depression and anxiety.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1172:

1. Golnasim Riahi, Marc Morissette, Pershia Samadi, Martin Parent, Thérèse Di Paolo, Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia, In Biochemical Pharmacology, Volume 86, Issue 7, 2013, Pages 970-978.