The AlphaLISA® Human RIG-I Binding Kit is designed to select and characterize compounds that specifically bind human RIG-I protein.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
RIG-I (Retinoic acid-Inducible Gene I) is a cytosolic pattern recognition receptor which is known to recognize RNA pathogens in cells. This protein triggers a type 1 interferon response and participates in the innate immune system. By identifying viral dsRNA, the RIG-I protein recognizes infected cells. The N-terminus of RIG-I contacts mitochondrial antiviral signaling proteins after being triggered by a dsRNA, thereby triggering the IFN-1 signaling pathway. Recent studies have shown that RIG-I is also involved in cancer, lupus nephritis, immunoglobulin A nephropathy, Crohn’s disease, and atherosclerosis.
Application |
Protein Binding
|
---|---|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Autoimmunity
|
Unit Size |
500 Assay Points
|
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