The AlphaLISA™ SureFire® Ultra™ Human and Mouse Total TFE3 assay is a sandwich immunoassay for quantitative detection of total TFE3 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
TFE3, or transcription factor E3, is a member of the basic helix-loop-helix leucine zipper MiT transcription factory family. MiT/TFE transcription factors play essential roles in the regulation of autophagy and lysosomal biogenesis. Phosphorylation is the primary regulator of MiT/TFE. The phosphorylated protein remains in the cytoplasm and, following dephosphorylation, translocates to the nucleus, where it induces autophagy and lysosomal biogenesis by promoting the expression of hundreds of genes. Several signaling molecules involved in the mTORC1, PKC, and AKT pathways can directly influence the transcription factor-mediated lysosome-to-nucleus signaling. TFE3 is associated with Parkinson’s disease, Alzheimer’s diseases, and various types of cancer.
The AlphaLISA SureFire Ultra Human and Mouse Total TFE3 Detection Kit is a sandwich immunoassay for the quantitative detection of total TFE3 in cellular lysates, using Alpha Technology.
Formats:
AlphaLISA SureFire Ultra kits are compatible with:
Alpha SureFire kits can be used for:
Automation Compatible |
Yes
|
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Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Predicted Species Reactivity |
Human
Mouse
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Shipping Conditions |
Shipped in Blue Ice
|
Therapeutic Area |
Neuroscience
Oncology
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Unit Size |
100 Assay Points
|
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