The AlphaLISA™ SureFire® Ultra™ Human Phospho-PKR (Thr451) assay is a sandwich immunoassay for quantitative detection of phospho-PKR (Thr451) in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Protein kinase R (PKR) is a kinase encoded by the EIF2AK2 gene and is involved in central cellular processes such as mRNA translation, transcriptional control, regulation of apoptosis, and proliferation. PKR plays a key role in the innate immunity pathway and is a mediator of the antiviral effects exerted by interferons. PKR also regulates eIF2α through phosphorylation. Dysregulation of PKR has been implicated in cancer, neurodegenerative disease, inflammation, and metabolic disorders.
The AlphaLISA SureFire Ultra Human Phospho-PKR (Thr451) assay is a sandwich immunoassay for the quantitative detection of phospho-PKR (Thr451) in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Target |
PKR
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Central Nervous System
Metabolic
Oncology
|
Unit Size |
10,000 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
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