The AlphaLISA™ SureFire® Ultra™ Human Phospho-MDM2 (Ser166) assay is a sandwich immunoassay for quantitative detection of phospho-MDM2 (Ser166) in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Murine Double Minute 2 (MDM2), is a protein that is involved in a variety of biological activities and is directly linked to DNA repair, cell cycle arrest, apoptosis, and the development of numerous illnesses. One of the most well-known E3 ligases, MDM2, is called upon by bifunctional PROTACs to cause ubiquitination and subsequent proteasomal destruction of a target protein. Identifying new PROTAC MDM2 ligands can improve selective proteasomal-dependent degradation of proteins of interest, involved in the onset of diseases such as cancers, neurodegenerative disease, and metabolic disorders.
The AlphaLISA SureFire Human Phospho-MDM2 (Ser166) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-MDM2 (Ser166) in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Target |
MDM2
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Oncology
|
Unit Size |
500 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
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