The AlphaLISA™ SureFire® Ultra™ Mouse Phospho-TDP-43 (Ser409/410) assay is a sandwich immunoassay for quantitative detection of phospho-TDP-43 (Ser409/410) in cellular lysates using Alpha Technology.
Feature | Specification |
---|---|
Application | Cell Signaling |
Sample Volume | 10 µL |
The AlphaLISA™ SureFire® Ultra™ Mouse Phospho-TDP-43 (Ser409/410) assay is a sandwich immunoassay for quantitative detection of phospho-TDP-43 (Ser409/410) in cellular lysates using Alpha Technology.
TAR DNA binding protein 43 (TDP-43) is a DNA and RNA-binding protein which plays a crucial role in RNA metabolism. Mainly located in the nucleus, TDP-43 shuttles between the nucleus and the cytoplasm. In pathological conditions, including stress or mutation, TDP-43 is mislocalized in the cytoplasm, which can be cleaved in C terminal fragments, thus leading to an accumulation of ubiquitinated and hyperphosphorylated toxic aggregates and then insoluble inclusion bodies. Aggregated TDP-43 has been identified as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), and more widely in several neurodegenerative diseases such as Alzheimer’s disease.
The AlphaLISA SureFire Mouse Phospho-TDP-43 (Ser409/410) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-TDP-43 (Ser409/410) in cellular lysates, using Alpha Technology.
Application |
Cell Signaling
|
---|---|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Modality |
Alpha
|
Lysis Buffer Compatibility |
Lysis Buffer
|
Molecular Modification |
Phosphorylation
|
Product Group |
Kit
|
Sample Volume |
10 µL
|
Shipping Conditions |
Shipped in Blue Ice
|
Target |
TDP-43
|
Target Class |
Phosphoproteins
|
Target Species |
Mouse
|
Technology |
Alpha
|
Therapeutic Area |
Neuroscience
|
Unit Size |
50,000 assay points
|
Are you looking for resources, click on the resource type to explore further.
Discover Alpha SureFire® Ultra™ assays, the no-wash cellular kinase assays leveraging Revvity's exclusive bead-based technology...
This document includes detailed tables listing HTRF™, AlphaLISA™ SureFire® Ultra™, and Alpha SureFire® Ultra™ Multiplex assays...
We are here to answer your questions.