The AlphaLISA™ SureFire® Ultra™ Human Total JAK1 assay is a sandwich immunoassay for quantitative detection of total JAK1 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases which include JAK2, JAK3, and TYK2. Numerous cytokines and growth factors, such as IL-6, IL-4, IFN-α, GM-CSF, induce the phosphorylation of JAKs. Activated JAK subsequently phosphorylates additional targets, including both cytokine receptors and major substrates, STATs. The JAK/STAT signaling pathway stimulates cell proliferation, differentiation, migration, and apoptosis. Alterations to JAK/STAT signaling reduce cytokine induced pro-inflammatory responses, making it an attractive target for anti-inflammatory therapies.
The AlphaLISA SureFire Human Total JAK1 Detection Kit is a sandwich immunoassay for the quantitative detection of total JAK1 in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Points |
500
|
Assay Target |
JAK1
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Autoimmunity
Oncology
|
Unit Size |
500 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
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