The AlphaLISA® SureFire® Ultra™ Human and Mouse Total IkBα assay is a sandwich immunoassay for quantitative detection of total IkBα in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor α (IkBα) is a member of a family of cellular proteins that function to inhibit NF-kB transcription factor. When IkBα is phosphorylated by IKKβ, this prevents IkBα from inhibiting NF-kB which then frees NF-kB and allows it to enter the nucleus of the cell, where it activates various genes involved in inflammation and other immune responses. The IKKβ signaling pathway is associated with numerous therapeutic areas, including diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, and many types of cancers.
The AlphaLISA SureFire Ultra Human and Mouse Total IkBα Detection Kit is a sandwich immunoassay for the quantitative detection of total IkBα in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Points |
500
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Target Species |
Human
Mouse
|
Therapeutic Area |
Autoimmunity
Immuno-oncology
Oncology
|
Unit Size |
500 Assay Points
|
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