The AlphaLISA™ SureFire® Ultra™ Human Total EGF Receptor L858R assay is a sandwich immunoassay for quantitative detection of total EGF Receptor L858R in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
Epidermal growth factor receptor (EGFR, EGF Receptor, Erb-1, or HER1) is a transmembrane protein and receptor for members of the epidermal growth factor (EGF) family. Binding of EGFR ligands drives receptor homodimerization or hetero-dimerization, leading to the activation of the EGFR tyrosine kinase domain and specific tyrosine residues. The signals transmitted from the EGF receptor to the nucleus lead to the regulation of various biological functions, such as cell proliferation, differentiation, survival, adhesion, migration, and angiogenesis. Mutations in EGFR, including mutation L858R in exon 21, result in EGFR overexpression and are associated with cancer.
The AlphaLISA SureFire Human Total EGF Receptor L858R Detection Kit is a sandwich immunoassay for the quantitative detection of total EGF Receptor L858R in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Target |
EGF Receptor
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Immuno-oncology
Oncology
|
Unit Size |
500 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
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