The AlphaLISA® SureFire® Ultra™ Human Aggregate DAP12 assay is a sandwich immunoassay for quantitative detection of aggregate DAP12 in cellular lysates using Alpha Technology.
DAP12, also known as TYRO protein tyrosine kinase-binding protein, functions as a signaling adapter for a number of innate immune system cell surface receptors. By activating SYK or Zap-70 and other downstream targets, crosslinking receptors linked to DAP12 causes tyrosine residues in their cytoplasmic ITAM to be phosphorylated by SRC family kinases, which initiates downstream signaling. By monitoring the neuronal surroundings and preserving a healthy brain homeostasis in microglia cells, the TREM2-DAP12 receptor complex seems to play an ongoing role.
The AlphaLISA SureFire Human Aggregate DAP12 Detection Kit is a sandwich immunoassay for the quantitative detection of aggregate DAP12 in cellular lysates, using Alpha Technology.
For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
Application |
Protein Detection
|
---|---|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
|
Therapeutic Area |
Neuroscience
|
Unit Size |
500 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
Are you looking for technical documents for this product. We have housed them in a dedicated section., click on the links below to explore.
We are here to answer your questions.