The AlphaLISA™ SureFire® Ultra™ Human and Mouse Total CREBBP assay is a sandwich immunoassay for quantitative detection of total CREBBP in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
The transcription coactivator CREB binding protein (CREBBP or CBP) is an acetyl transferase, that mediates histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. CREBBP/CBP inhibitors and degraders reduce H3K27ac, down-regulate oncogene transcription, induce cancer cell growth inhibition and cell death, activate immune response, overcome drug resistance and suppress tumor progression in vivo. CREBBP/CBP is over-expressed in cancer cells and in drug-resistant cancer cells, it activates oncogene transcription and induces cancer cell proliferation, survival, tumorigenesis, metastasis, immune evasion and drug-resistance.
The AlphaLISA SureFire Human and Mouse Total CREBBP Detection Kit is a sandwich immunoassay for the quantitative detection of total CREBBP in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Target |
CREBBP
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Experimental Type |
In vitro
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
Mouse
|
Therapeutic Area |
Oncology
|
Unit Size |
100 Assay Points
|
This guide outlines further possible optimization of cellular and immunoassay parameters to ensure the best possible results are...
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