The AlphaLISA™ SureFire® Ultra™ Human Total CDK12 assay is a sandwich immunoassay for quantitative detection of total CDK12 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
Feature | Specification |
---|---|
Application | Cell Signaling |
Sample Volume | 10 µL |
The AlphaLISA™ SureFire® Ultra™ Human Total CDK12 assay is a sandwich immunoassay for quantitative detection of total CDK12 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
Cyclin-dependent kinase 12 (CDK12) is a transcription-associated CDK. It complexes with Cyclin K to regulate gene transcription elongation via phosphorylating RNA polymerase II and regulates the expression of genes involved in DNA repair. CDK12 also plays a role in RNA splicing, cell cycle progression, cell proliferation, DNA damage response (DDR), and the maintenance of genomic stability. Mutation or amplification of CDK12 is closely related to tumorigenesis, associated with cancers such as breast, colorectal, liver, lung, ovarian, prostate, and bladder.
The AlphaLISA SureFire Human Total CDK12 Detection Kit is a sandwich immunoassay for the quantitative detection of total CDK12 in cellular lysates, using Alpha Technology.
Application |
Cell Signaling
|
---|---|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Modality |
Alpha
|
Lysis Buffer Compatibility |
Lysis Buffer
|
Molecular Modification |
Total
|
Product Group |
Kit
|
Sample Volume |
10 µL
|
Shipping Conditions |
Shipped in Blue Ice
|
Target |
CDK12
|
Target Class |
Phosphoproteins
|
Target Species |
Human
|
Technology |
Alpha
|
Therapeutic Area |
Oncology
|
Unit Size |
500 Assay Points
|
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