AlphaLISA SureFire Ultra Human & Mouse Total BCL-XL Detection Kit, 500 Assay Points

B-cell lymphoma-extra large (BCL-XL) is a member of the BCL-2 protein family resulting in apoptosis inhibition or pro-survival function. Beclin 1, a key factor in autophagy regulation, interacts with BCL-XL. BCL-XL is also essential for the survival of neurons and is involved in protective roles in neuronal injuries. Numerous cancers and other diseases are associated with BCL-XL, including acute lymphoblastic leukemia, non-Hodgkin’s lymphoma, small cell lung cancer, breast cancer, gastric cancer, prostate cancer, and neurodegenerative disorders.

The AlphaLISA SureFire Human and Mouse Total BCL-XL Detection Kit is a sandwich immunoassay for the quantitative detection of total BCL-XL in cellular lysates, using Alpha Technology.

Formats:

• The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
• The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
• The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
• The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

• Cell and tissue lysates
• Antibody modulators
• Biotherapeutic antibodies

Alpha SureFire kits can be used for:

• Cellular kinase assays
• Receptor activation studies
• Screening