The AlphaLISA™ SureFire® Ultra™ Human and Mouse Total ATF-4 assay is a sandwich immunoassay for quantitative detection of total ATF-4 in cellular lysates using Alpha Technology.
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption and disposal requirements under European REACH regulations (EC 1907/2006).
Activating transcription factor 4 (ATF-4), also known as tax-responsive enhancer element B67, is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF-4 is a member of a family of DNA-binding proteins that includes AP-1 family, CREBs, and CREB-like proteins, all of which share a leucine zipper region that is involved in protein-protein interactions. Under stress conditions, PERK pathway rapidly stimulates the expression of NRF2 through activating transcription factor 4 (ATF4) that contributes to the NRF2 protective response.
The AlphaLISA SureFire Human and Mouse Total ATF-4 Detection Kit is a sandwich immunoassay for the quantitative detection of total ATF-4 in cellular lysates, using Alpha Technology.
Application |
Protein Analysis & Detection
Protein Detection
|
---|---|
Assay Target |
ATF-4
|
Assay Target Class |
Phospho-protein
|
Assay Technology |
Alpha
|
Automation Compatible |
Yes
|
Brand |
AlphaLISA SureFire Ultra
|
Detection Method |
Alpha
|
Shipping Conditions |
Shipped in Blue Ice
|
Target Species |
Human
Mouse
|
Therapeutic Area |
Oncology
|
Unit Size |
50,000 Assay Points
|
Protein phosphorylation, regulated by kinase and phosphatase cascades, plays a crucial role in cellular processes. Monitoring...
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