250 µCi quantities of 8-Hydroxy-DPAT, [Propyl-2,3-ring-1,2,3-³H]-, are available for research. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a highly selective full agonist of the 5-HT1A receptor that also stimulates the 5-HT7 receptor and has been shown to label 5-hydroxytryptamine (5-HT) reuptake sites. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems, and modulate the release of neurotransmitters and hormones. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET929:

1. Vidal R., Linge R., Castillo M.J., Amigó J., Valdizán E.M., Castro E. (2016) Autoradiographic Visualization of G Protein-Coupled Receptors in Brain. In: Luján R., Ciruela F. (eds) Receptor and Ion Channel Detection in the Brain. Neuromethods, vol 110. Humana Press, New York, NY.
2. Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, et al. Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice, Evidence-Based Complementary and Alternative Medicine, Volume 2015, 2015.
3. Kiyoshi Terawaki, Yasushi Ikarashi, Kyoji Sekiguchi, Yoichiro Nakai, Yoshio Kase. Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells, In Journal of Ethnopharmacology, Volume 127, Issue 2, 2010, Pages 306-312.