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Application Note

Investigate mechanism of action of drugs targeting TDP-43 phosphorylation and aggregation with HTRF-based detection assays

Discover the power of HTRF for TDP-43 phosphorylation and aggregation investigations

The trans-activator response (TAR) DNA-binding protein (TDP-43) acts as a shuttle, transporting nucleic acid between the cell nucleus and cytoplasm and participating in RNA metabolism. Its involvement in neurogenerative disease is thoroughly described through hyperphosphorylation, ubiquitination, cleavage of C-terminal fragments, and aggregation leading to neurotoxic effects.

In this application note, you will discover the:

  • Measurement of aggregated TDP-43 phosphorylation using different compounds modulating the TDP-43 signaling pathway
  • Study of different models and states of TDP-43 for investigating diverse drugs actions

For research use only. Not for use in diagnostic procedures.

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Investigate mechanism of action of drugs targeting TDP-43 phosphorylation and aggregation with HTRF-based detection assays

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