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Application Note

Target essentiality assay

Target selection is a crucial step in the successful development of therapeutics. As part of target selection, it can be important to determine whether or not a specific gene is essential for survival and/or proliferation in a given cell line.

Read this application note to learn about Revvity's essentiality assay - a novel medium-throughput assay for analyzing gene essentiality in cell lines that are amenable to single cell dilution cloning. This method should aid both the understanding of whether the protein from a target gene of interest needs to be completely absent for a phenotypic effect or whether reduced expression is good enough to induce the phenotype of interest.

Such data can support the development of more robust cancer therapeutics by increasing confidence in target selection.

For research use only. Not for use in diagnostic procedures.

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Target essentiality assay

Download Application Note