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Application Note
Biochemical binding ADCC assays utilizing AlphaLISA toolbox reagents for the characterization of hIgGs and FcγR1A
In this application note we demonstrate the ease with which AlphaLISA toolbox reagents can be used to develop any FcγR binding assay across the various stages of biologics research and development, including therapeutic screening and GMP Lot Release.
Application Note
A fast and simple chemiluminescent assay for monitoring of DNA-protein interactions
In this application note, we use HepG2 nuclear extracts to demonstrate the binding of Sp1 and HNF1 transcription factors to tagged oligonucleotides containing required cognate response elements. Read this note to see the results and access detailed data compared to EMSA.
Whitepaper
Shifting the treatment paradigm: the promise of gene therapy for neurodegenerative diseases
Traditional treatments for neurodegenerative diseases focus on managing symptoms, but recent advancements in gene therapy offer hope for more effective and sustainable solutions. Read now!
Product Info
LANCE and LANCE Ultra TR-FRET technology product list
LANCE™ Ultra is a highly sensitive and highly reproducible no-wash proximity assay technology that combines the benefits of time resolution (TR) with fluorescence resonance energy transfer (FRET).
Whitepaper
Targeted protein degradation: A novel therapeutic strategy for neurodegenerative diseases
In this white paper, get details about TPD that offers a novel strategy for neurodegenerative diseases by degrading disease-linked proteins, showing promise in preclinical studies.
Technical Note
A simple method for preparing GPCR membrane model extracts from stable cell lines for use with the HTRF GTP Gi binding assay
This Technical Note provides a detailed method for preparing GPCR membrane model extracts from stable cell lines for use with the HTRF GTP Gi binding assay, including cell culture preparation, cell lysis, membrane extraction, and assay optimization.
Product Note
Automated characterization of proteins and nucleic acids
Streamline your slab gel electrophoresis, while providing increased throughput and the data formats required for biotherapeutics and genomics workflows.
Application Note
Characterizing chemokine receptor inhibitors with AlphaLISA SureFire Ultra, Alpha SureFire Ultra Multiplex and LANCE Ultra cAMP assays
This application note demonstrates how the SureFire Ultra and LANCE Ultra cAMP assays can be used for measuring inhibitors to CCR7 and CXCR2 cell surface receptors using a cellular model system where these receptors are overexpressed in CHO cells.
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