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Literature - Publication Review

Utility of engineered human Neural Stem Cells -NSCs- expressing varying exon 1 HTT fragments to study Huntington---s disease

Huntington's disease (HD) is a rare, progressive neurodegenerative disorder that usually presents itself with symptoms of motor and cognitive decline between the ages of 30 and 50. It is most commonly caused by an expansion mutation in the CAG trinucleotide repeat within exon 1 of the HTT gene which codes for the protein huntingtin and is inherited in an autosomal dominant manner. This literature review explores the use of a human neural stem cells to express varying exon 1 HTT fragments to study HD.

For research use only. Not for use in diagnostic procedures.

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Utility of engineered human Neural Stem Cells -NSCs- expressing varying exon 1 HTT fragments to study Huntington---s disease

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