The maintenance of proteostasis, the biological mechanisms that control the fate of a protein from synthesis to degradation, is ensured by complex and interconnected pathways controlling protein abundance, turnover, folding, functions, subcellular localization, and ultimate degradation. Impaired proteostasis can lead to the accumulation of damaged or aggregated proteins, or conversely, to excessive protein degradation. Proteostasis is thus involved in pathologies such as cancer, autoimmune diseases, and neurodegenerative disorders.
This protein degradation booklet helps scientists and researchers appreciate and navigate the diversity of molecular pathways associated with protein degradation.
Check out this exclusive guide that includes:
For research use only. Not for use in diagnostic procedures.
Protein degradation awareness in a single guide