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Technical Note
PROTAC degraders targeting CDK4/CDK6 for the study of cell cycle regulation in oncology
The cell cycle is tightly regulated by key proteins like Cyclin D1, which forms complexes to initiate progression through phases like G1 into S and G2. Dysregulation of these proteins, including Cyclin A2, Cyclin B1, Cyclin D1, and Cyclin E1, can serve as prognostic biomarkers in cancer, potentially driving uncontrolled proliferation and cancer progression.
Discover insights on cell cycle regulation in this technical note using AlphaLISA™ SureFire® Ultra™ immunoassay technology, investigating molecular responses to PROTAC and NRG1 treatments. Download the full document to learn more.
For research use only. Not for use in diagnostic procedures.
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PROTAC degraders targeting CDK4/CDK6 for the study of cell cycle regulation in oncology