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Application Note

Optimizing ternary complex assays with AlphaLISA Toolbox reagents for targeted protein degradation applications

Using AlphaLISA technology to unleash the power of Targeting Protein Degradation (TPD)

Targeted Protein Degradation (TPD) uses heterobifunctional small molecule “degraders”, such as PROTAC® Degraders, to achieve inactivation of target proteins in cells. These degraders take advantage of the ubiquitin-proteasome system to knockdown a protein of interest.

In this Application Note, discover how easily Revvity AlphaLISA toolbox reagents are used to detect ternary complex with variable ligases, protein partners, and PROTAC molecules.

For research use only. Not for use in diagnostic procedures.

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Optimizing ternary complex assays with AlphaLISA Toolbox reagents for targeted protein degradation applications

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