Integrins as targets for immunotherapy

Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as in the progression of disease states such as cancer.

Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where it may enable tumors to evade the immune system. Revvity’s IVISense^® Integrin Receptor (IntegriSense™) fluorescent probes are designed to target αvβ3 integrin to help researchers better understand how cancer cells hijack normal integrin-related cell signaling and cell adhesion processes that promote tumor growth and metastases, as well as investigating the potential of integrin-blocking cancer immunotherapies.

For research use only. Not for use in diagnostic procedures.