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Application Note
Improve PROTAC Targeting Kinase Discovery with HTRF Binding Kits
HTRF assays to assess PROTAC® compounds
Kinases constitute about 2% of all human genes and are essential proteins involved in signal transduction. They regulate numerous biological events, such as cell growth and proliferation. Kinase dysfunctions are associated with numerous diseases and current treatments have many side effects. Targeted degradation could be an option to overcome these, and PROteolysis Targeting Chimera (PROTAC®) is one of the latest trending tools. This is why we have prepared a note compiling experiments carried out to characterize PROTAC® compounds using HTRF™ technology.
Featured in this note:
- Assay principle and workflow
- Freshly published graphs and data
- Informative materials and methods, including references
For research use only. Not for use in diagnostic procedures.
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Improve PROTAC Targeting Kinase Discovery with HTRF Binding Kits