This application note shows you how to determine the relative affinity of different therapeutic antibodies to FcRn, and how it can be used to compare biosimilars. It contains experiments and data that investigate the specificity of the assays for binding the Fc portion of an antibody, and the binding performance of different subtypes. It features:
For research use only. Not for use in diagnostic procedures.
FcRn binding assays using AlphaLISA and HTRF technologies