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Application Note

CDK signaling in oncology- assess the effectiveness of a CDK9-targeting PROTAC molecule

CDK9 is an attractive target for cancer therapeutics due to its crucial role in transcription regulation, particularly of short-lived anti-apoptotic proteins such as MCL-1 and XIAP which are critical to the survival of cancer cells. One approach for specifically degrading CDK9 is using a proteolysis targeting chimera (PROTAC).

In this application note, you will discover:

  • The rapid and strong effect of CDK9 PROTAC molecule Thal-SNS-032, demonstrating specificity in CDK9 degradation
  • How HTRF® and AlphaLISA®SureFire® Ultra™ are used to measure protein levels, with each tool showcasing the ability of PROTACs to rapidly degrade a targeted protein making it a unique tool in the fight against cancer

For research use only. Not for use in diagnostic procedures.

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CDK signaling in oncology- assess the effectiveness of a CDK9-targeting PROTAC molecule

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