Mitochondrial dynamics are essential for energy conversion and neuron survival. Understanding changes in mitochondrial dynamics is therefore crucial in developing mitochondria-based therapy options for complex pathological conditions such as cancer, neurological disorders, and metabolic syndromes. Fast kinetic live-cell imaging combined with high-content screening represents a promising strategy to quantitatively track these changes in real time and at large scale.
This application note demonstrates how to investigate mitochondrial dynamics in human iPSC-derived neurons using the Operetta® CLS™ high-content analysis system.
For research use only, not for use in diagnostic procedures.
Analysis of mitochondrial dynamics in human iPSC-derived neurons using the Operetta CLS High-Content Analysis System